Long-Term Metabolic Effects and Recurrence of Weight Gain a Decade Post Roux-en-Y Gastric Bypass: Findings from a Longitudinal Cohort Analysis - Summary - MDSpire
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Long-Term Metabolic Effects and Recurrence of Weight Gain a Decade Post Roux-en-Y Gastric Bypass: Findings from a Longitudinal Cohort Analysis
To explore long-term recurrent weight gain (RWG) and metabolic outcomes after Roux-en-Y gastric bypass (RYGB), and to identify baseline clinical characteristics that may predict weight gain, which is crucial for improving patient outcomes.
Key Findings:
Mean RWG from 2 to 10 years was 26.0%, indicating a significant trend in weight regain.
311 out of 554 patients (56%) attended the 10-year follow-up, highlighting potential selection bias.
83.9% of attendees had also participated in the 5-year follow-up, suggesting a commitment to long-term follow-up.
Interpretation:
Despite RWG, RYGB may still provide long-term metabolic benefits, though the extent of weight regain varies among individuals, potentially impacting overall health outcomes.
Limitations:
Only 56% of eligible patients attended the 10-year follow-up, which may introduce selection bias.
The study was conducted at a single tertiary referral center, limiting generalizability.
Potential confounding factors related to lifestyle changes post-surgery were not fully addressed.
Conclusion:
RYGB can lead to significant long-term metabolic benefits, but a notable proportion of patients experience RWG, which may impact overall health outcomes.
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