Robustness of radiomics within photon-counting detector CT: impact of acquisition and reconstruction factors

To assess the impact of acquisition and reconstruction factors on the robustness of radiomics in photon-counting detector CT (PCD-CT).

Radiomics features exhibit limited stability across PCD-CT and dual-energy CT systems.
Acquisition and reconstruction parameters significantly influence the variability of radiomics feature values.
The study identified 18 first-order and 75 texture radiomics features, highlighting the complexity of feature stability.

These findings underscore the necessity for standardization in radiomics research to ensure robustness across imaging modalities.

The phantom study design may not fully replicate clinical conditions, limiting the applicability of results.
The scarcity of literature on PCD-CT radiomics restricts the generalizability of the findings.

Understanding the impact of acquisition and reconstruction factors is essential for improving the robustness of radiomics in clinical applications.