The mediating role of the aggregate index of systemic inflammation between childhood emotional neglect and depressive severity in major depressive disorder: a cross-sectional study - Summary - MDSpire
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The mediating role of the aggregate index of systemic inflammation between childhood emotional neglect and depressive severity in major depressive disorder: a cross-sectional study
To explore the associations among childhood trauma, inflammation, and depressive severity, with a focus on the mediating role of the Aggregate Index of Systemic Inflammation (AISI) in the relationship between childhood emotional neglect and depressive severity.
Key Findings:
MDD patients with childhood trauma had higher inflammatory markers and depressive severity.
Emotional neglect was a significant predictor of HAMD-24 scores.
AISI was a significant inflammatory marker predicting HAMD-24 scores.
Emotional neglect correlated positively with AISI and HAMD-24 scores.
AISI partially mediated the relationship between childhood emotional neglect and depressive severity, with a mediation effect of 28.07%.
Interpretation:
Limitations:
Causal relationships cannot be established.
Study design is cross-sectional, limiting temporal conclusions.
Potential confounding factors were not fully controlled.
