Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as acute small intestinal perforation: a case report and exploratory BCL-2–targeted therapy - Summary - MDSpire
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Monomorphic epitheliotropic intestinal T-cell lymphoma presenting as acute small intestinal perforation: a case report and exploratory BCL-2–targeted therapy
To report a rare case of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) presenting with acute gastrointestinal perforation and to describe the use of an exploratory regimen combining a BCL-2 inhibitor (Venetoclax) with CHOP chemotherapy.
Key Findings:
Emergency surgery revealed MEITL, initially staged as Lugano stage I.
Immunohistochemistry showed tumor cells were CD3 (weakly positive), CD8+, CD56+, Bcl-2 (3+), and Ki-67 (~60%).
The patient achieved complete metabolic remission after four cycles of Venetoclax plus CHOP.
Interpretation:
Limitations:
Next-generation sequencing to identify mutations was not performed due to clinical urgency.
The findings regarding complete metabolic remission require validation in larger studies.
Conclusion:
Incorporating BCL-2 inhibition into the treatment of Bcl-2–high MEITL may represent a biologically rational strategy.
