To investigate whether restoring endogenous melatonin rhythms improves clinical outcomes, particularly focusing on inflammation reduction, in oesophageal cancer survivors.
Key Findings:
76% of rhythm-blunted survivors achieved a melatonin amplitude ≥ 2.5 by 12 months.
Composite inflammation score decreased by −0.30 ± 0.18 in the intervention group compared to −0.03 ± 0.15 in the control group (p < 0.001).
Circadian restoration was associated with a 62% lower hazard of recurrence, cardiovascular events, second primaries, or death.
Interpretation:
Behavioural realignment of melatonin rhythms is linked to reduced systemic inflammation and fewer adverse events in oesophageal cancer survivors, suggesting a potential strategy for improving long-term health outcomes.
Limitations:
The study was conducted in a specific geographic region, which may limit generalizability.
Potential confounding factors not fully accounted for in the analysis, including lifestyle habits and treatment patterns.
Conclusion:
Routine circadian-hygiene counselling combined with salivary monitoring may support long-term health in oesophageal cancer survivors, emphasizing the importance of melatonin rhythm restoration.
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