Topical trichloroacetic acid versus electrocautery for treatment of anal intraepithelial neoplasia in people living with HIV: a multicentre, randomised, non-inferiority trial (TECAIN-study) - Summary - MDSpire
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Topical trichloroacetic acid versus electrocautery for treatment of anal intraepithelial neoplasia in people living with HIV: a multicentre, randomised, non-inferiority trial (TECAIN-study)
To compare the efficacy, safety, and impact on HPV parameters of topical TCA treatment versus electrocautery (ECA) for the treatment of anal intraepithelial neoplasia (AIN) in people living with HIV (PLWH).
Approach:
Treatment Procedures: High-resolution anoscopy (HRA)-guided treatment was conducted for all visible lesions at baseline, with optional follow-up treatments allowed every four weeks based on clinical assessment.
Key Findings:
Topical TCA demonstrated comparable efficacy to ECA in managing AIN.
TCA treatment was associated with fewer side effects compared to ECA.
The study provided insights into the clinical and histological responses to both treatment modalities.
Interpretation:
The findings suggest that TCA may be a viable alternative to ECA for treating AIN in PLWH, potentially with a better safety profile.
Limitations:
The study was open-label, which may introduce bias.
Masking was not possible for clinical investigators and patients due to the nature of the treatments.
Conclusion:
Topical TCA may offer an effective and less complex treatment option for AIN in PLWH compared to ECA.
by Stefan Esser, Alexander Kreuter, Anja Potthoff, Robert Jablonka, Mark Oette, Martin F. Sprinzl, Daniel Exner, Konstantinos Bilbilis, Hildegard Lax, Eva-Maria Huessler, Steffi Silling, Ulrike Wieland
