Systemic immune-inflammation index predicts post-thrombectomy outcomes and reveals a mediating role in the association between neurocardiac stress and prognosis: a multicenter study - Summary - MDSpire

Systemic immune-inflammation index predicts post-thrombectomy outcomes and reveals a mediating role in the association between neurocardiac stress and prognosis: a multicenter study

  • By

  • Long Yang

  • Han Zhao

  • Qingtao Xie

  • Qitong Chen

  • Yehong Liu

  • Hailiang Li

  • Jun Lu

  • Bo Du

  • Jiheng Hao

  • Jiyou Yu

  • Chao Sun

  • Yu Liu

  • Yujia Zhai

  • Haibing Liao

  • Yiming Yin

  • Hui Chen

  • Qiuchen Zhao

  • Yu Feng

  • May 29, 2026

  • 0 min

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Objective:

To investigate the role of the Systemic Immune-Inflammation Index (SII) in the association between atrial fibrillation with rapid ventricular response (AF-RVR) and poor outcomes in stroke patients undergoing endovascular thrombectomy (EVT).

Key Findings:
  • Poor outcomes occurred in 56.1% of the derivation cohort.
  • AF-RVR was associated with elevated SII.
  • Patients with both AF-RVR and high SII had a significantly increased risk of poor outcome (adjusted OR 9.80).
  • Mediation analysis indicated a significant indirect effect of AF-RVR through SII (absolute risk difference 4.6 percentage points).
  • The model demonstrated good discrimination (AUC 0.789 derivation, 0.710 validation).
Interpretation:

Remove this section.

Limitations:
  • Retrospective design may introduce bias.
  • Single-center data collection for external validation may limit generalizability.
  • Potential confounding factors not accounted for in the model.
Conclusion:

Revise to eliminate implications and focus on findings.

Original Source(s)

Systemic immune-inflammation index predicts post-thrombectomy outcomes and reveals a mediating role in the association between neurocardiac stress and prognosis: a multicenter study

  • by Long Yang, Han Zhao, Qingtao Xie, Qitong Chen, Yehong Liu, Hailiang Li, Jun Lu, Bo Du, Jiheng Hao, Jiyou Yu, Chao Sun, Yu Liu, Yujia Zhai, Haibing Liao, Yiming Yin, Hui Chen, Qiuchen Zhao, Yu Feng

  • May 29, 2026

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