To summarize advances in ultrasound-driven mechanical immunomodulation in tumor treatment and its effects on immune cells and the tumor microenvironment.
Key Findings:
Mechanical properties of tumors create barriers that restrict drug and immune cell infiltration.
Ultrasound can deliver programmable mechanical stimuli to enhance tumor response to immunotherapy.
Current evidence supports ultrasound's role in reshaping the tumor immune microenvironment.
Interpretation:
Ultrasound offers a noninvasive method to overcome physical barriers in tumors, potentially enhancing the effectiveness of immunotherapy.
Limitations:
Evidence linking ultrasound effects to immune outcomes is fragmented.
Challenges remain in standardizing ultrasound parameters for clinical application.
Conclusion:
Ultrasound-mediated mechanical immunomodulation presents a promising avenue for improving tumor responses to treatment, necessitating further research to optimize its clinical application.
