Global trends in systemic sclerosis-related mortality, 2001–2023: an epidemiological analysis using World Health Organization mortality data - Summary - MDSpire
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Global trends in systemic sclerosis-related mortality, 2001–2023: an epidemiological analysis using World Health Organization mortality data
To evaluate changes in systemic sclerosis (SSc) mortality trends from 2001 to 2023, stratified by age, sex, and geographic region, to identify high-risk populations and inform public health strategies, emphasizing the significance of these findings.
Key Findings:
85,291 SSc-related deaths reported across 74 countries from 2001 to 2023, with mortality rates contextualized against population sizes.
Leading causes of SSc mortality were other forms of SSc (48.64%) and unspecified SSc (35.43%).
SSc-related deaths predominantly occurred in women (79.40%).
Age-specific SSc crude mortality rates increased with age, peaking at 13.55 per 1,000,000 in the 80-84 age group.
Interpretation:
The study highlights a significant and increasing trend in SSc mortality, particularly among older women, indicating a need for targeted public health interventions, such as increased screening and awareness programs.
Limitations:
Data quality varied by country, potentially affecting the reliability of mortality statistics and introducing biases in data collection.
Exclusion of countries with low data quality or zero reported SSc deaths may limit the generalizability of findings.
Conclusion:
This study provides new insights into the global burden of systemic sclerosis mortality, emphasizing the need for improved awareness and healthcare strategies for affected populations, particularly in high-risk demographics.
