Heart Failure is an Independent Risk Factor for Incident Hip, Proximal Humerus, and Wrist Fractures in a High-Risk Older Population - Summary - MDSpire
To examine the association of heart failure (HF) with incident hip, proximal humerus, and wrist fractures in older adults initiating osteoporosis therapy.
Approach:
Key Findings:
HF was independently associated with a 48% increased risk of hip fractures (aHR 1.48).
HF was associated with a 46% increased risk of proximal humerus fractures (aHR 1.46).
HF was linked to a 37% increased risk of wrist fractures (aHR 1.37).
Cumulative fracture incidence was significantly higher in individuals with HF compared to those without.
Interpretation:
HF is a significant independent risk factor for non-vertebral osteoporotic fractures in older adults, highlighting the need for targeted management strategies.
Limitations:
Lack of data on HF subtype, severity, and pharmacotherapy.
Absence of information on frailty, functional status, kidney function, and bone density.
Conclusion:
HF should be considered a critical risk factor for fractures in older adults on osteoporosis therapy, necessitating comprehensive management strategies that include lifestyle interventions.
Adults assigned to nonnutritive sweetened beverages or water maintained weight reductions through 104 weeks, with no statistically significant difference between groups.
