AD Not Linked to Early CV Risk Markers
Repeated assessments from childhood to early adulthood did not identify consistent cardiometabolic risk patterns by disease activity or severity.
By
Kathryn Wighton
May 27, 2026
Objective: To investigate the association between active atopic dermatitis (AD) and early cardiovascular (CV) risk markers in pediatric and adolescent patients.
Key Findings: No consistent association between active AD and cardiometabolic risk scores at ages 15 and 17 years. Two nominal associations with low-density lipoprotein cholesterol (LDL-C) were observed. AD trajectory phenotypes were not consistently associated with cardiovascular risk factors at ages 17 and 24 years. Moderate-frequent AD at age 17 and severe-frequent AD at age 24 were associated with lower HDL-C. Mild-intermittent AD at age 17 was associated with slightly higher diastolic blood pressure. Interpretation:
Limitations: Attrition over more than 2 decades of follow-up. Limited detailed skin measures. No correction for multiple testing. Predominantly White cohort. Relatively few participants with severe AD. Conclusion:
