AD Not Linked to Early CV Risk Markers - Summary - MDSpire
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AD Not Linked to Early CV Risk Markers

Repeated assessments from childhood to early adulthood did not identify consistent cardiometabolic risk patterns by disease activity or severity.

  • By

  • Kathryn Wighton

  • May 27, 2026

  • 5 min

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Objective:

To investigate the association between active atopic dermatitis (AD) and early cardiovascular (CV) risk markers in pediatric and adolescent patients.

Key Findings:
  • No consistent association between active AD and cardiometabolic risk scores at ages 15 and 17 years.
  • Two nominal associations with low-density lipoprotein cholesterol (LDL-C) were observed.
  • AD trajectory phenotypes were not consistently associated with cardiovascular risk factors at ages 17 and 24 years.
  • Moderate-frequent AD at age 17 and severe-frequent AD at age 24 were associated with lower HDL-C.
  • Mild-intermittent AD at age 17 was associated with slightly higher diastolic blood pressure.
Interpretation:

Limitations:
  • Attrition over more than 2 decades of follow-up.
  • Limited detailed skin measures.
  • No correction for multiple testing.
  • Predominantly White cohort.
  • Relatively few participants with severe AD.
Conclusion:

Original Source(s)

AD Not Linked to Early CV Risk Markers

  • by Kathryn Wighton

  • May 27, 2026

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