AD Not Linked to Early CV Risk Markers
Repeated assessments from childhood to early adulthood did not identify consistent cardiometabolic risk patterns by disease activity or severity.
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By
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Kathryn Wighton
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May 27, 2026
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Objective:
To investigate the association between active atopic dermatitis (AD) and early cardiovascular (CV) risk markers in pediatric and adolescent patients.
Key Findings:
- No consistent association between active AD and cardiometabolic risk scores at ages 15 and 17 years.
- Two nominal associations with low-density lipoprotein cholesterol (LDL-C) were observed.
- AD trajectory phenotypes were not consistently associated with cardiovascular risk factors at ages 17 and 24 years.
- Moderate-frequent AD at age 17 and severe-frequent AD at age 24 were associated with lower HDL-C.
- Mild-intermittent AD at age 17 was associated with slightly higher diastolic blood pressure.
Interpretation:
Limitations:
- Attrition over more than 2 decades of follow-up.
- Limited detailed skin measures.
- No correction for multiple testing.
- Predominantly White cohort.
- Relatively few participants with severe AD.
Conclusion:
