Investigating the association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and the risk of carotid artery plaque in patients with first-ever ischemic stroke based on different glucose metabolic conditions - Summary - MDSpire
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Investigating the association between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and the risk of carotid artery plaque in patients with first-ever ischemic stroke based on different glucose metabolic conditions
To investigate the association between the LDL-C/HDL-C ratio and carotid plaque risk in patients with first-ever ischemic stroke, focusing on differences across glucose metabolic conditions.
Approach:
Study Design: A retrospective study involving 12,166 patients hospitalized for first-time ischemic stroke from January 1, 2013, to May 1, 2023.
Data Analysis: Logistic regression, stratified analysis, and exploratory mediation analyses were employed to assess the LDL-C/HDL-C–carotid plaque risk association.
Key Findings:
77.8% of participants had carotid plaque.
LDL-C/HDL-C showed a stronger association with carotid plaque risk than other lipid parameters.
The association was stronger in the Pre-DM cohort (OR: 1.233, 95% CI: 1.093–1.391) compared to those with diabetes mellitus (OR: 1.178, 95% CI: 1.074–1.293).
No significant association was found in individuals with normal glucose regulation.
HbA1c and FPG accounted for 11.5% and 10.5% of the LDL-C/HDL-C–carotid plaque risk association, respectively.
Interpretation:
Elevated LDL-C/HDL-C is significantly associated with carotid atherosclerosis in ischemic stroke patients, particularly in those with prediabetes.
Limitations:
Retrospective design may limit causality inference.
Potential confounding factors not fully controlled.
Conclusion:
The study indicates that LDL-C/HDL-C may be associated with the risk of lipid-glucose co-morbidity in the context of ischemic stroke.
