Impact of trigger-day serum luteinizing hormone levels on embryo quality and pregnancy outcomes in overweight and obese women undergoing GnRH antagonist protocols: a retrospective cohort study - Summary - MDSpire
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Impact of trigger-day serum luteinizing hormone levels on embryo quality and pregnancy outcomes in overweight and obese women undergoing GnRH antagonist protocols: a retrospective cohort study
To investigate the impact of trigger-day serum LH levels on IVF-ET outcomes in overweight and obese women undergoing GnRH antagonist protocols, highlighting the significance of these findings in the context of existing literature.
Key Findings:
Group 1 had significantly more follicles ≥14 mm, retrieved/mature/fertilized oocytes, and high-quality embryos than Groups 2 and 3 (all P < 0.05).
LH levels were negatively correlated with ovarian response and embryo quality indicators (all P < 0.05).
No significant differences in clinical pregnancy or live birth rates were observed among the groups (all P > 0.05), indicating that LH levels do not predict these outcomes.
Interpretation:
Elevated trigger-day LH levels correlate with poorer ovarian response and embryo quality in overweight and obese women, but do not predict pregnancy outcomes, suggesting a need for tailored clinical approaches.
Limitations:
Retrospective design may introduce selection bias, potentially affecting the generalizability of the findings.
Findings may not be applicable to all overweight and obese populations, limiting their broader relevance.
Conclusion:
While elevated LH levels are associated with reduced ovarian response and embryo quality, they do not independently predict IVF success in overweight and obese women, emphasizing the need for further research.
