A clinically applicable nomogram predicting non-return to work in young and middle-aged patients with acute large vessel occlusion stroke: integrating neurological function and psychosocial factors for personalized rehabilitation - Summary - MDSpire

A clinically applicable nomogram predicting non-return to work in young and middle-aged patients with acute large vessel occlusion stroke: integrating neurological function and psychosocial factors for personalized rehabilitation

  • By

  • Yu Ding

  • Jingling Zhu

  • Yiling He

  • Xiuling Yang

  • Wenfei Liang

  • Kangqiang Yang

  • Xiaoling Wu

  • Guoshun Li

  • Jiasheng Zhao

  • Zhan Zhao

  • Jingyi Chen

  • Qiuxing He

  • Weimin Ning

  • June 24, 2026

  • 0 min

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Objective:

To identify key predictors of non-return to work (non-RTW) in young and middle-aged patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO) after endovascular therapy (EVT) and develop a nomogram for risk stratification.

Approach:
  • Study Design: Retrospective cohort study involving 350 AIS-LVO patients who underwent EVT at Dongguan Hospital from July 2018 to July 2025.
  • Predictor Identification: Potential predictors were selected using LASSO regression; independent predictors identified via multivariable logistic regression.
  • Nomogram Development: A nomogram was constructed and assessed for discrimination (AUC), calibration (calibration curves, Hosmer–Lemeshow test), and clinical utility (decision curve analysis).
Key Findings:
  • Six independent predictors of non-RTW identified: IADL, admission NIHSS score, NRS-2002 score, balance impairment (BBS), post-stroke rehabilitation, and anxiety-depressive state.
  • Nomogram demonstrated robust discriminative performance (AUC = 0.858, 95% CI: 0.812–0.903).
  • Calibration curves confirmed favorable calibration between predicted and observed probabilities.
Interpretation:

The nomogram enables early risk stratification and personalized rehabilitation planning for young and middle-aged AIS-LVO patients post-EVT.

Limitations:
  • Single-center study may limit generalizability.
  • Retrospective design may introduce selection bias.
Conclusion:

The developed nomogram provides a clinically actionable tool for predicting non-RTW in young and middle-aged AIS-LVO patients after EVT.

Original Source(s)

A clinically applicable nomogram predicting non-return to work in young and middle-aged patients with acute large vessel occlusion stroke: integrating neurological function and psychosocial factors for personalized rehabilitation

  • by Yu Ding, Jingling Zhu, Yiling He, Xiuling Yang, Wenfei Liang, Kangqiang Yang, Xiaoling Wu, Guoshun Li, Jiasheng Zhao, Zhan Zhao, Jingyi Chen, Qiuxing He, Weimin Ning

  • June 24, 2026

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