To investigate the relationship between cognitive performance and future depression risk in individuals with remitted depression compared to matched controls.
Key Findings:
Participants with remitted depression had higher odds of experiencing future depression compared to controls.
33% of participants with remitted depression experienced depressive relapse compared to 13% of controls who developed first-episode depression.
Lower baseline cognitive performance in controls was associated with higher future depression risk.
Among participants with remitted depression, higher cognitive performance was linked to greater future depression risk.
Interpretation:
Limitations:
Estimated timing of depressive episodes during follow-up may not be accurate.
Incomplete cognitive data could affect results.
Limited power for resting-state functional MRI analyses.
Population representativeness is limited, with over 95% of participants being White.
