Evidence for exponential progression in advanced Parkinson’s disease: retrospective analysis of a prospective cohort study - Summary - MDSpire

Evidence for exponential progression in advanced Parkinson’s disease: retrospective analysis of a prospective cohort study

  • By

  • Sophie Merve Yener

  • Catherine Ding

  • Ganga Ganesvaran

  • Jane E. Alty

  • Benjamin G. Clissold

  • Craig D. McColl

  • Katrina A. Reardon

  • Mark Schiff

  • Peter A. Kempster

  • June 5, 2026

  • 0 min

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Objective:

To analyze motor progression in advanced Parkinson's disease (PD) and explore the possibility of exponential progression in the final disease stage.

Key Findings:
  • Median age at death was 78.4 years.
  • Mean disease duration was 14.5 years.
  • Late off scores progressed significantly faster compared to earlier disease segments (p < 0.001).
  • Cognitive impairment had a strong effect on progression rates.
Interpretation:

Limitations:
  • Small sample size of 34 patients.
  • Lack of detailed cause of death information for the entire cohort.
  • No autopsies performed to confirm pathological findings.
Conclusion:

Original Source(s)

Evidence for exponential progression in advanced Parkinson’s disease: retrospective analysis of a prospective cohort study

  • by Sophie Merve Yener, Catherine Ding, Ganga Ganesvaran, Jane E. Alty, Benjamin G. Clissold, Craig D. McColl, Katrina A. Reardon, Mark Schiff, Peter A. Kempster

  • June 5, 2026

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