Objective:

To evaluate urinary FABP2 levels in pediatric patients to determine its potential as a non-invasive biomarker of intestinal integrity in celiac disease.

Approach:

Key Findings:

• FABP2 levels were significantly elevated in active CeD patients (47.7pg/ml) compared to controls (9.65pg/ml) (p<0.05).
• FABP2 levels in CeD patients on GFD were not significantly different (15.0pg/ml).
• ROC curve analysis indicated FABP2 has diagnostic potential for celiac disease (AUC= 0.7269; cut off = 23.7pg/ml; sensitivity = 66.7%, specificity=76.9%).

Interpretation:

Urinary FABP2 reflects intestinal epithelial injury and may serve as a non-invasive biomarker for assessing gut integrity and disease activity in celiac disease.

Limitations:

• The study is retrospective and cross-sectional.
• Larger prospective studies and histological correlation are needed to validate the diagnostic utility of FABP2.

Conclusion:

Urinary FABP2 may be a useful non-invasive biomarker for intestinal damage in celiac disease, pending further validation.

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