To clarify the association between admission hyperglycemia (AH) and long-term functional outcomes after mechanical thrombectomy (MT) in acute ischemic stroke patients, emphasizing the potential impact on clinical practice, and to determine if this association is mediated by postoperative renal function.
Key Findings:
49.9% of patients had admission hyperglycemia (AH).
A good outcome at 6 months was achieved in 38.0% of patients.
AH was significantly associated with a lower likelihood of a good outcome (OR 3.148, 95% CI: 1.672–5.925, p < 0.001).
Lower postoperative estimated glomerular filtration rate (post-eGFR) was also associated with a lower likelihood of a good outcome (OR 0.978, 95% CI: 0.963–0.993, p = 0.004).
Post-eGFR mediated 25.57% of the total effect of AH on good prognosis.
Interpretation:
Admission hyperglycemia is independently associated with long-term functional outcomes after mechanical thrombectomy in acute ischemic stroke patients, with postoperative renal function partially mediating this association, highlighting the need for careful glycemic management.
Limitations:
The study is limited to a single center, which may affect generalizability.
The observational nature of the study may introduce confounding factors, potentially impacting the reliability of the findings.
Conclusion:
Admission hyperglycemia is associated with long-term functional outcomes in acute ischemic stroke patients undergoing mechanical thrombectomy, potentially mediated by postoperative renal function.
