Case Report: Tumor regression and neurological recovery in paraplegia from POLD1-mutated hepatocellular carcinoma treated with targeted immunotherapy and electroacupuncture - Summary - MDSpire

Case Report: Tumor regression and neurological recovery in paraplegia from POLD1-mutated hepatocellular carcinoma treated with targeted immunotherapy and electroacupuncture

  • By

  • Xionghao Pang

  • Xinyi Zhao

  • Jiajian Lin

  • Yansu Wang

  • Liang Xiao

  • Meixiang Li

  • Lin Dong

  • Yaoguang Xie

  • Lingzhi Jiang

  • Caiping Yang

  • Geng Tian

  • June 1, 2026

  • 0 min

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Objective:

To analyze a case of hepatocellular carcinoma (HCC) with bone metastasis and paraplegia, exploring the effects of targeted immunotherapy and electroacupuncture on tumor response and neurological recovery.

Key Findings:
  • Complete response of the tumor observed after three months of targeted immunotherapy.
  • Patient achieved independent walking ability with a walker at 28-month follow-up.
  • Significant increases in cytokines IL-1β, TNF-α, and IFN-γ were noted during treatment and rehabilitation.
Interpretation:

The case presents observations regarding the POLD1 mutation and its context in HCC treatment, but causality cannot be established.

Limitations:
  • Findings are based on a single case study, limiting generalizability.
  • No direct evidence linking immunotherapy to accelerated neural recovery.
Conclusion:

The observations require further investigation in prospective studies to explore the mechanisms of treatment effects on tumor and neurological recovery.

Original Source(s)

Case Report: Tumor regression and neurological recovery in paraplegia from POLD1-mutated hepatocellular carcinoma treated with targeted immunotherapy and electroacupuncture

  • by Xionghao Pang, Xinyi Zhao, Jiajian Lin, Yansu Wang, Liang Xiao, Meixiang Li, Lin Dong, Yaoguang Xie, Lingzhi Jiang, Caiping Yang, Geng Tian

  • June 1, 2026

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