Management of clinical failure after minimally invasive surgical therapies (MIST) for BPH: repeat MIST versus resection, enucleation or ablation—a narrative review from EAU endourology - Summary - MDSpire

Management of clinical failure after minimally invasive surgical therapies (MIST) for BPH: repeat MIST versus resection, enucleation or ablation—a narrative review from EAU endourology

  • By

  • Bogatova, Svetlana

  • Morozov, Andrey

  • Gauhar, Vineet

  • Lifshitz, David

  • Sukhanov, Roman

  • Ehrlich, Yaron

  • Asali, Murad

  • Krupinov, German

  • Golan, Shay

  • Somani, Bhaskar K.

  • Herrmann, Thomas R. W.

  • Enikeev, Dmitry

  • February 27, 2026

  • 0 min

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Objective:

To determine whether failure of minimally invasive surgical therapies (MIST) for benign prostatic hyperplasia (BPH) justifies a repeat MIST or if traditional approaches like TURP or EEP are preferable, focusing on patient outcomes and clinical effectiveness.

Key Findings:
  • MIST techniques like PUL, iTIND, and Rezum have limited literature due to their recent adoption, which may affect their perceived efficacy.
  • PAE and Aquablation are better studied due to earlier introduction into clinical practice, providing a more robust evidence base.
  • TURP remains a common retreatment option after MIST failures due to its proven efficacy and established long-term outcomes.
Interpretation:

While MIST offers reduced invasiveness and preservation of sexual function, their long-term effectiveness compared to traditional methods remains uncertain, necessitating careful consideration in retreatment decisions, particularly in light of the limited data available.

Limitations:
  • Limited number of studies on newer MIST techniques may hinder understanding of their effectiveness.
  • Potential bias due to the small volume of literature on certain MIST methods could impact clinical decision-making.
Conclusion:

The choice between repeat MIST and traditional surgical options should be guided by individual patient circumstances, the specific MIST technique used initially, and the available evidence on outcomes.

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