A double-edged sword: the role of macrophage pyroptosis-driven cytokine storm-mediated intercellular communication in tumor progression - Summary - MDSpire
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The Dual Role of Macrophage Pyroptosis-Induced Cytokine Storms in Tumor Development
To examine how macrophage pyroptosis-driven cytokine storms influence tumor progression.
Approach:
Mechanisms of Pyroptosis: Pyroptosis is executed through canonical (caspase-1/NLRP3-dependent) and non-canonical (caspase-4/5/11-dependent) pathways, leading to the cleavage of gasdermin D (GSDMD) and the release of pro-inflammatory cytokines.
Impact on Tumor Immunity: Acute, moderate inflammatory responses activate anti-tumor immunity, while chronic, low-grade cytokine storms promote tumorigenesis through various mechanisms.
Clinical Investigations: Pyroptosis-related biomarkers may support patient stratification and treatment-response prediction in tumors rich in tumor-associated macrophages (TAMs).
Future Research Directions: Future studies should focus on quantitative mapping of macrophage pyroptosis, development of tumor-targeted inducers, and establishment of pyroptosis-based biomarker panels.
Key Findings:
Pyroptosis can induce both anti-tumor immunity and promote tumorigenesis depending on the inflammatory response's intensity and duration.
Chronic cytokine storms contribute to genomic instability, cancer stem cell enrichment, and immunosuppressive microenvironments.
