Efficacy of Jishi Shuanghua Granules in preventing radiation-induced esophagitis in non-small cell lung cancer patients undergoing concurrent chemoradiotherapy: protocol for a multicenter, randomized, double-blind, placebo-controlled trial - Summary - MDSpire

Efficacy of Jishi Shuanghua Granules in preventing radiation-induced esophagitis in non-small cell lung cancer patients undergoing concurrent chemoradiotherapy: protocol for a multicenter, randomized, double-blind, placebo-controlled trial

  • By

  • Huakang Li

  • Yuanzhen Mi

  • Ke Xu

  • Ming Fan

  • Jun Yin

  • Qiang Li

  • Ziliang Wu

  • Cuicui Gong

  • Yunjing Jia

  • Pengxuan Gu

  • Shanshan Wei

  • Zhonglin Zhang

  • Shuo Zhang

  • Yuanyuan Zheng

  • Bing Lin

  • Jinyi Lang

  • Biao Zhao

  • Meihua Chen

  • June 23, 2026

  • 0 min

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Objective:

To assess the effectiveness of Jishi Shuanghua Granules (JSG) in mitigating the risk and severity of acute radiation-induced esophagitis (ARIE) in patients with non-small cell lung cancer (NSCLC) receiving concurrent chemoradiotherapy (CCRT).

Approach:
    Key Findings:
    • ARIE is a common complication in NSCLC patients undergoing CCRT, affecting quality of life and treatment outcomes.
    • JSG is a Traditional Chinese Medicine formulation that has been used clinically for over ten years but lacks robust evidence from structured studies.
    • Existing treatments for ARIE primarily focus on symptomatic relief, highlighting a need for effective preventive measures.
    Interpretation:

    Limitations:
    • Previous studies on herbal formulations for ARIE have been limited by small sample sizes and methodological rigor.
    • The trial's findings may be influenced by the specific characteristics of the patient population and the clinical setting.
    Conclusion:

    This study aims to fill the evidence gap regarding the efficacy and safety of JSG in ARIE prevention, potentially enhancing treatment protocols for NSCLC patients.

    Sources:

Original Source(s)

Efficacy of Jishi Shuanghua Granules in preventing radiation-induced esophagitis in non-small cell lung cancer patients undergoing concurrent chemoradiotherapy: protocol for a multicenter, randomized, double-blind, placebo-controlled trial

  • by Huakang Li, Yuanzhen Mi, Ke Xu, Ming Fan, Jun Yin, Qiang Li, Ziliang Wu, Cuicui Gong, Yunjing Jia, Pengxuan Gu, Shanshan Wei, Zhonglin Zhang, Shuo Zhang, Yuanyuan Zheng, Bing Lin, Jinyi Lang, Biao Zhao, Meihua Chen

  • June 23, 2026

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