Objective:

To investigate the association between the posterior precortical vitreous pocket (PPVP) and retinal morphological and blood flow parameters, with the aim of elucidating its potential pathophysiological significance.

Key Findings:

• PPVP detected in 72.3% of subjects.
• PPVP-positive group showed greater retinal thickness in superior inner macula (362.91 ± 16.84 μm vs. 344.06 ± 15.59 μm, p < 0.001) and nasal inner macula (361.96 ± 16.83 μm vs. 348.00 ± 15.45 μm, p = 0.003).
• Larger volume in superior inner macula for PPVP-positive group (0.58 ± 0.05 vs. 0.54 ± 0.06, p = 0.001).
• Higher vessel density in superficial nasal retina (34.13 ± 7.88 vs. 23.83 ± 11.09, p = 0.001) and deep nasal retina (36.66 ± 6.58 vs. 25.44 ± 13.83, p = 0.004) for PPVP-positive group.

Interpretation:

The presence of PPVP is significantly associated with localized retinal thickening, increased retinal volume, and enhanced retinal blood flow, suggesting its influence on the vitreoretinal interface through biomechanical or microcirculatory mechanisms.

Limitations:

• Single-center study may limit generalizability.
• Sample size of 65 may not capture broader population variations, potentially affecting the robustness of the findings.

Conclusion:

PPVP may influence retinal structure and blood flow, contributing to understanding the physiological vitreoretinal interface and its implications for retinal disorders, warranting further research.