Comparison of anti-human T cell globulins on immune reconstitution and early infections after autologous transplant in patients with multiple sclerosis - Summary - MDSpire

Comparison of anti-human T cell globulins on immune reconstitution and early infections after autologous transplant in patients with multiple sclerosis

  • By

  • Johanna Richter

  • Nico Gagelmann

  • Felix Fischbach

  • Kristin Rathje

  • Lena Kristina Pfeffer

  • Boris Fehse

  • Anita Badbaran

  • Susanna Carolina Berger

  • Rolf Krause

  • Evgeny Klyuchnikov

  • Christine Wolschke

  • Catherina Lueck

  • Francis Ayuk

  • Manuel A. Friese

  • Christoph Heesen

  • Nicolaus Kröger

  • November 27, 2025

  • 0 min

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Objective:

To evaluate the effects of ATG and ATLG on immune reconstitution and early infectious complications, specifically EBV and CMV reactivations, following cyclophosphamide-based AHSCT in patients with MS.

Key Findings:
  • Patients receiving pre-transplant ATLG exhibited significantly faster immune reconstitution at day 30 compared to those receiving post-transplant ATG, which may lead to reduced early infection rates.
Interpretation:

The study suggests that the timing of ATG and ATLG administration may influence the speed of immune reconstitution in MS patients undergoing AHSCT.

Limitations:
  • The study had a limited sample size and was conducted at a single center, which may introduce biases affecting the generalizability of the findings.
Conclusion:

Pre-transplant ATLG may provide a more favorable immune reconstitution profile compared to post-transplant ATG in MS patients undergoing AHSCT, suggesting a need for reevaluation of treatment protocols.

Original Source(s)

Comparison of anti-human T cell globulins on immune reconstitution and early infections after autologous transplant in patients with multiple sclerosis

  • by Johanna Richter, Nico Gagelmann, Felix Fischbach, Kristin Rathje, Lena Kristina Pfeffer, Boris Fehse, Anita Badbaran, Susanna Carolina Berger, Rolf Krause, Evgeny Klyuchnikov, Christine Wolschke, Catherina Lueck, Francis Ayuk, Manuel A. Friese, Christoph Heesen, Nicolaus Kröger

  • November 27, 2025

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