Development and validation of a clinical prediction model for poor ovarian response in assisted reproductive technology
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By
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Xin Xin
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Zhaoxia Cheng
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Ting Hu
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Yi Guo
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Nan Li
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Junbo Zhao
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Shuaishuai Guo
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June 15, 2026
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Objective:
To develop and validate a predictive model for poor ovarian response (POR) in patients undergoing Assisted Reproductive Technology (ART).
Approach:
Key Findings:
- The final model identified AMH, basal FSH, BMI, and antral follicle count as significant predictors of POR.
- The model exhibited high discriminatory ability and good calibration across training, internal validation, and test datasets.
- A nomogram was developed from the model for individualized risk prediction.
Interpretation:
The stepwise logistic regression model provides predictive accuracy and clinical utility for managing ART.
Limitations:
- The study is retrospective and may have inherent biases.
- Only one stimulation cycle per woman was included, which may limit generalizability.
Conclusion:
The study presents a predictive model for POR in ART.