Development and validation of a clinical prediction model for poor ovarian response in assisted reproductive technology - Summary - MDSpire

Development and validation of a clinical prediction model for poor ovarian response in assisted reproductive technology

  • By

  • Xin Xin

  • Zhaoxia Cheng

  • Ting Hu

  • Yi Guo

  • Nan Li

  • Junbo Zhao

  • Shuaishuai Guo

  • June 15, 2026

  • 0 min

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Objective:

To develop and validate a predictive model for poor ovarian response (POR) in patients undergoing Assisted Reproductive Technology (ART).

Approach:
    Key Findings:
    • The final model identified AMH, basal FSH, BMI, and antral follicle count as significant predictors of POR.
    • The model exhibited high discriminatory ability and good calibration across training, internal validation, and test datasets.
    • A nomogram was developed from the model for individualized risk prediction.
    Interpretation:

    The stepwise logistic regression model provides predictive accuracy and clinical utility for managing ART.

    Limitations:
    • The study is retrospective and may have inherent biases.
    • Only one stimulation cycle per woman was included, which may limit generalizability.
    Conclusion:

    The study presents a predictive model for POR in ART.

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