Ionizing Radiation Promotes Expansion of a p90RSK-Activated Subset of Patrolling Monocytes: Influence of Colchicine - Summary - MDSpire

Ionizing Radiation Promotes Expansion of a p90RSK-Activated Subset of Patrolling Monocytes: Influence of Colchicine

  • By

  • Masaki Imanishi

  • Venkata S. K. Samanthapudi

  • Nhat-Tu Le

  • Luis Antonio Rivera

  • Jung Hyun Kim

  • Jonghae Lee

  • Gilbert F. Mejia

  • Oanh Hoang

  • Anita Deswal

  • Keri L. Schadler

  • Michelle A. T. Hildebrandt

  • Syed Wamique Yusuf

  • Guangyu Wang

  • Jared K. Burks

  • Roza I. Nurieva

  • Nicolas L. Palaskas

  • Kevin T. Nead

  • El-ad David Amir

  • Efstratios Koutroumpakis

  • Steven H. Lin

  • Jun-ichi Abe

  • Sivareddy Kotla

  • April 15, 2026

  • 0 min

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Objective:

To investigate the effects of colchicine on immune cell remodeling, particularly focusing on the activation and expansion of specific monocyte subsets following ionizing radiation (IR) exposure.

Key Findings:
  • IR exposure did not change overall immune cell frequency but increased myeloid and B cell populations with colchicine treatment.
  • IR enhanced p90RSK activation in CD14−CD16+ monocytes while reducing proliferation and inflammatory markers.
  • Colchicine suppressed the IR-induced expansion of CD14−CD16+CD68hi monocytes without restoring DNMT3A or TET2 expression.
Interpretation:

Colchicine selectively inhibits the expansion of a specific monocyte subset activated by p90RSK following IR, suggesting a novel mechanism for modulating radiation-induced inflammation and potential therapeutic implications.

Limitations:
  • Study conducted on a single healthy donor, limiting generalizability to broader populations.
  • In vitro findings may not fully replicate in vivo responses, necessitating further investigation.
Conclusion:

Colchicine may mitigate radiation-induced immune remodeling and cardiovascular risk in cancer survivors by targeting specific monocyte signaling pathways, warranting further clinical exploration.

Original Source(s)

Ionizing Radiation Promotes Expansion of a p90RSK-Activated Subset of Patrolling Monocytes: Influence of Colchicine

  • by Masaki Imanishi, Venkata S. K. Samanthapudi, Nhat-Tu Le, Luis Antonio Rivera, Jung Hyun Kim, Jonghae Lee, Gilbert F. Mejia, Oanh Hoang, Anita Deswal, Keri L. Schadler, Michelle A. T. Hildebrandt, Syed Wamique Yusuf, Guangyu Wang, Jared K. Burks, Roza I. Nurieva, Nicolas L. Palaskas, Kevin T. Nead, El-ad David Amir, Efstratios Koutroumpakis, Steven H. Lin, Jun-ichi Abe, Sivareddy Kotla

  • April 15, 2026

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