Epithelial cell proliferation on anterior surface of intraocular lens after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery: a case report - Summary - MDSpire

Epithelial cell proliferation on anterior surface of intraocular lens after Descemet stripping automated endothelial keratoplasty (DSAEK) surgery: a case report

  • By

  • Ali Zare

  • Mozhgan Rezaei Kanavi

  • Sepehr Feizi

  • Fariba Pirsarabi

  • Faezeh Tajari

  • June 17, 2026

  • 0 min

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Objective:

To describe a rare case of epithelial cell proliferation on the anterior surface of an intraocular lens (IOL) following Descemet stripping automated endothelial keratoplasty (DSAEK), including clinical course, diagnostic challenges, and histopathological findings.

Approach:
    Key Findings:
    • Epithelial cell proliferation on the IOL surface was confirmed through histopathological assessment.
    • The opacification was localized to the anterior surface of the IOL, associated with microcracks and cellular imprints.
    • No calcium deposits were found on the IOL surface.
    Interpretation:

    Epithelial cell proliferation on IOLs is a rare but significant cause of visual impairment, potentially linked to surgical trauma and chronic inflammation.

    Limitations:
    • The study is based on a single case report, limiting generalizability.
    • The underlying mechanisms and risk factors for epithelial cell proliferation remain poorly understood.
    Conclusion:

    Epithelial cell proliferation on IOLs following DSAEK can lead to significant visual disturbances.

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