Objective:

To investigate the independent association between low platelet-to-white blood cell ratio (PWR) and the increased incidence and severity of hemorrhagic transformation (HT) following intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) patients.

Approach:

Key Findings:

• Patients with HT had lower PWR levels compared to those without HT.
• The highest PWR quartile (Q4) was associated with a reduced risk of HT (OR: 0.33; 95% CI: 0.18–0.61).
• The nomogram achieved an AUC of 0.767 (95% CI: 0.716–0.818) for predicting HT risk.

Interpretation:

Limitations:

• Retrospective design may introduce bias.
• Single-center study limits generalizability.

Conclusion:

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