Assessment of the Frequency of Psychological Comorbidities and Their Impact on Injection Therapy Results in Individuals with Chronic Low Back Pain: A Retrospective Cohort Analysis Using Registry Data - Summary - MDSpire

Assessment of the Frequency of Psychological Comorbidities and Their Impact on Injection Therapy Results in Individuals with Chronic Low Back Pain: A Retrospective Cohort Analysis Using Registry Data

  • By

  • Anas Afifi

  • Khaled Allan

  • Marc Brügmann

  • Andrea Roth-Daniek

  • Rolf Sobottke

  • Moh’d Yazan Khasawneh

  • Koroush Kabir

  • Alba Shehu

  • Michel Teuben

  • Ümit Mert

  • Maher Ghandour

  • Mohamad Agha Mahmoud

  • April 28, 2026

  • 0 min

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Objective:

To assess the prevalence of psychological disorders in patients with chronic low back pain (CLBP) and radicular pain (RP) and evaluate their association with pain severity and response to lumbar injection therapy, specifically distinguishing between the two conditions.

Key Findings:
  • 37.6% of patients had depression; prevalence estimates were 41% (HADS) and 31% (DASS).
  • Anxiety was present in 28-31% of patients; stress symptoms were reported in 45%.
  • Chronic pain disorder diagnosed in 17.1% of patients.
  • Patients with psychological comorbidities reported higher baseline NRS scores and smaller reductions in pain post-treatment.
Interpretation:

Psychological comorbidities are prevalent in CLBP and RP patients, correlating with greater pain severity and less improvement from injection therapy, highlighting the need for integrated psychological assessment in treatment strategies.

Limitations:
  • Retrospective design limits causal inference.
  • Psychological assessment served only as a characterization tool, not influencing treatment decisions.
  • Potential biases inherent in retrospective studies may affect the results.
Conclusion:

The findings underscore the importance of integrating psychological assessment and intervention in the multidisciplinary management of CLBP to enhance treatment outcomes.

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