To characterize coronary microvascular function in patients with sepsis-associated myocardial injury using invasive thermodilution-based assessment.
Approach:
Study Design: A prospective observational study examining the association between plasma hs-cTnT concentrations and IMR in sepsis patients.
Patient Population: Consecutive adults aged 40–85 with sepsis or septic shock and myocardial injury were enrolled. Exclusion criteria included prior coronary artery bypass grafting and severe chronic kidney disease.
Coronary Angiography and Assessment: Coronary angiography and microvascular function assessment were performed after clinical stabilization, using thermodilution-derived indices.
Key Findings:
Coronary microvascular dysfunction (CMD) is linked to myocardial injury in sepsis as demonstrated in the study.
The prevalence of obstructive coronary artery disease (CAD) in sepsis patients was not clearly defined in the study.
Invasive indices like IMR and MRR were utilized to quantify microvascular function in the study.
Interpretation:
The study hypothesizes that greater impairment in microvascular function correlates with higher hs-cTnT concentrations.
Limitations:
The study was limited to patients with specific inclusion and exclusion criteria.
The findings may not be generalizable to all sepsis patients as per the study's design.
Conclusion:
The study aims to elucidate the relationship between coronary microvascular function and myocardial injury in sepsis.
by Samantha Lörstad, Per Åstrand, Patrik Gille-Johnson, Yunzhang Wang, Christina Ekenbäck, Fadi Jokhaji, Felix Böhm, Patrik Hjalmarsson, Shajan Shekarestan, Tomas Jernberg, Sara Tehrani, Kambiz Shahgaldi, Jonas Persson
