To explore the relationship between serum uric acid (sUA) and incident coronary artery calcification (CAC) in a Chinese population.
Approach:
Study Design: A retrospective cohort study involving 6,996 participants without CAC at baseline, assessed through low-dose chest computed tomography.
Data Analysis: Multivariable Cox regression was used to evaluate the association between sUA levels and the risk of developing incident CAC.
Key Findings:
During a median follow-up of 6.0 years, 560 participants (8.0%) developed incident CAC.
Each standard deviation increase in sUA was associated with a higher risk of incident CAC (HR: 1.21, 95% CI: 1.09–1.35, P < 0.001).
Participants with hyperuricemia had a significantly higher risk of incident CAC compared to those with normal uric acid levels (HR: 1.31, 95% CI: 1.08–1.58, P = 0.005).
A linear dose–response association was observed between sUA levels and the risk of incident CAC.
Interpretation:
Limitations:
The study is retrospective and may be subject to selection bias.
The findings may not be generalizable to populations outside of the Chinese demographic.
