Emergence of Severe and Prolonged Hepatobiliary Disorders Following COVID-19 Infection: A Systematic Analysis - Summary - MDSpire

Emergence of Severe and Prolonged Hepatobiliary Disorders Following COVID-19 Infection: A Systematic Analysis

  • By

  • Ali Aboulwafa

  • Ahamed Lebbe

  • Aya Khalil

  • Nuran Bayraktar

  • Beshr Mushannen

  • Sama Ayoub

  • Shaunak Sarker

  • Marwan Nour Abdalla

  • Sa’ad Laws

  • Ibrahim Mohammed

  • Lina Yagan

  • Malik Mushannen

  • Dalia Zakaria

  • February 4, 2026

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Objective:

To compile published data reporting fatal, severe, or long-term complications impacting the biliary system post-COVID-19 infection, specifically focusing on the definition of long-COVID.

Approach:
    Key Findings:
    • 23 studies met inclusion criteria after screening 38,148 titles and abstracts, involving a total of X patients.
    • Hepatobiliary disorders included post-COVID-19 cholangitis, cholecystitis, and hepatitis, affecting Y, Z, and W patients respectively.
    • COVID-19 has emerged as a significant contributor to both acute and chronic liver injuries.
    Interpretation:

    The findings indicate a notable prevalence of severe hepatobiliary complications following COVID-19, suggesting the need for ongoing monitoring and management of liver health in recovered patients to improve clinical outcomes.

    Limitations:
    • Exclusion of non-English studies may limit generalizability and introduce language bias.
    • Potential biases in study selection and data extraction processes.
    Conclusion:

    The study highlights the importance of recognizing and addressing hepatobiliary disorders as significant long-term complications of COVID-19.

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