Emergence of Severe and Prolonged Hepatobiliary Disorders Following COVID-19 Infection: A Systematic Analysis - Summary - MDSpire

Emergence of Severe and Prolonged Hepatobiliary Disorders Following COVID-19 Infection: A Systematic Analysis

  • By

  • Ali Aboulwafa

  • Ahamed Lebbe

  • Aya Khalil

  • Nuran Bayraktar

  • Beshr Mushannen

  • Sama Ayoub

  • Shaunak Sarker

  • Marwan Nour Abdalla

  • Sa’ad Laws

  • Ibrahim Mohammed

  • Lina Yagan

  • Malik Mushannen

  • Dalia Zakaria

  • February 4, 2026

  • 0 min

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Objective:

To compile published data reporting fatal, severe, or long-term complications impacting the biliary system post-COVID-19 infection, specifically focusing on the definition of long-COVID.

Key Findings:
  • 23 studies met inclusion criteria after screening 38,148 titles and abstracts, involving a total of X patients.
  • Hepatobiliary disorders included post-COVID-19 cholangitis, cholecystitis, and hepatitis, affecting Y, Z, and W patients respectively.
  • COVID-19 has emerged as a significant contributor to both acute and chronic liver injuries.
Interpretation:

The findings indicate a notable prevalence of severe hepatobiliary complications following COVID-19, suggesting the need for ongoing monitoring and management of liver health in recovered patients to improve clinical outcomes.

Limitations:
  • Exclusion of non-English studies may limit generalizability and introduce language bias.
  • Potential biases in study selection and data extraction processes.
Conclusion:

The study highlights the importance of recognizing and addressing hepatobiliary disorders as significant long-term complications of COVID-19.

Original Source(s)

Emergence of Severe and Prolonged Hepatobiliary Disorders Following COVID-19 Infection: A Systematic Analysis

  • by Ali Aboulwafa, Ahamed Lebbe, Aya Khalil, Nuran Bayraktar, Beshr Mushannen, Sama Ayoub, Shaunak Sarker, Marwan Nour Abdalla, Sa’ad Laws, Ibrahim Mohammed, Lina Yagan, Malik Mushannen, Dalia Zakaria

  • February 4, 2026

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