Association between maternal thyroid function and adverse outcomes of pregnant women and offspring: evidence from an umbrella review - Summary - MDSpire
To rigorously evaluate the existing evidence linking maternal thyroid dysfunction with adverse outcomes in pregnant women and their offspring, emphasizing the clinical significance of these findings.
Key Findings:
Thyroid hormones are crucial for fetal growth and brain development, with specific emphasis on the impact of thyroid dysfunction.
Thyroid dysfunction during pregnancy is linked to adverse outcomes such as miscarriage, preterm delivery, and neurodevelopmental deficiencies, supported by relevant statistics.
Inconsistent results exist regarding the relationship between gestational diabetes and thyroid diseases, warranting further investigation.
Interpretation:
The review highlights the need for clarity on the risks associated with maternal thyroid dysfunction during pregnancy and suggests areas for future research.
Limitations:
Controversial epidemiological characteristics of thyroid dysfunction in pregnancy, including potential biases in the studies reviewed.
Lack of uniform standards for interventions and management strategies, indicating a need for consensus in clinical practice.
Conclusion:
This umbrella review provides a comprehensive evaluation of the associations between maternal thyroid dysfunction and adverse pregnancy outcomes, underscoring the importance of addressing the identified gaps in research.
Surveys captured nearly 7 times as many menopause observations as structured clinical records, with high agreement when both sources identified menopause.
