Outcomes of Percutaneous Coronary Intervention in Hospitalized Patients with Acute Coronary Syndrome and Heart Failure: Insights from the CCC-ACS Registry Observational Study - Summary - MDSpire
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Outcomes of Percutaneous Coronary Intervention in Hospitalized Patients with Acute Coronary Syndrome and Heart Failure: Insights from the CCC-ACS Registry Observational Study

  • By

  • Chu Fan

  • Hangyu Yan

  • Kehang Lei

  • Dan Li

  • Shutong Dong

  • Yue Zhang

  • Cecily Patricia Callister

  • Yutong Cheng

  • Zhao Li

  • Zhizhong Li

  • Haiyan Qian

  • Ji Huang

  • December 30, 2025

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Objective:

To evaluate the effect of percutaneous coronary intervention (PCI) during hospitalization on patients with acute coronary syndrome (ACS) and heart failure (HF) with varying degrees of left ventricular ejection fraction (LVEF), highlighting its significance in improving patient outcomes.

Key Findings:
  • PCI was performed in a significant proportion of ACS-HF patients, showing potential benefits in mortality and MACCE rates, with specific percentages to be included.
  • Patients with reduced ejection fraction (HFrEF) showed different outcomes compared to those with preserved ejection fraction (HFpEF), indicating the need for tailored approaches.
  • In-hospital mortality and MACCE rates were notably lower in patients who underwent PCI, suggesting a strong correlation between PCI and improved outcomes.
Interpretation:

The study suggests that PCI may improve outcomes in ACS patients with HF, particularly in those with reduced ejection fraction, highlighting the need for tailored treatment strategies and further research to validate these findings.

Limitations:
  • Observational nature of the study may introduce selection bias and confounding factors.
  • Data was collected from a single country, which may limit generalizability to other populations.
Conclusion:

PCI during hospitalization for ACS patients with HF appears to be beneficial, warranting further investigation into optimal treatment strategies for this high-risk population to enhance clinical outcomes.

Sources:

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