Oxidative stress markers in bipolar disorder and first-degree relatives: differential associations of ischemia-modified albumin and superoxide dismutase - Summary - MDSpire
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Oxidative stress markers in bipolar disorder and first-degree relatives: differential associations of ischemia-modified albumin and superoxide dismutase
To evaluate thiol-disulfide homeostasis, ischemia-modified albumin, ferroxidase, and superoxide dismutase levels in patients with bipolar disorder, their unaffected first-degree relatives, and healthy controls.
Approach:
Sample Analysis: Fasting blood samples analyzed for TDH parameters, IMA, ferroxidase, and SOD; statistical tests included ANOVA and multivariable linear regression analyses.
Key Findings:
IMA levels were significantly higher in BD patients than in HCs (β = 0.17, p = 0.007).
SOD levels were significantly elevated in both BD (β = 0.37, p = 0.015) and FDR groups (β = 0.41, p = 0.009) compared with HCs.
Differences in thiol parameters between BD and FDR groups were not significant after adjustment for age.
Ferroxidase levels did not differ significantly between groups.
Modest discriminative performance for IMA and SOD was observed (AUC range: 0.63–0.66).
Interpretation:
Elevated IMA levels in BD may reflect oxidative stress, while increased SOD levels in both BD patients and unaffected FDRs may indicate a potential familial link.
Limitations:
Modest discriminative performance of biomarkers.
Cross-sectional design limits causal inference.
Need for longitudinal studies to clarify the role of biomarkers.
Conclusion:
The study suggests potential roles of IMA and SOD as biomarkers in bipolar disorder, but further research is necessary to establish their significance.
