Physicians’ acceptance of large language model–based clinical decision support tools in gynecologic oncology: a technology acceptance model study - Summary - MDSpire

Physicians’ acceptance of large language model–based clinical decision support tools in gynecologic oncology: a technology acceptance model study

  • By

  • Jan Lennart Stalp

  • Juliane Alexandra Schneider

  • Anna Krause

  • Lena Steinkasserer

  • Jens Hachenberg

  • Agnieszka Denecke

  • Peter Hillemanns

  • Dominik Wolff

  • July 14, 2026

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Objective:

To evaluate the clinical technology acceptance of large language model-based clinical decision support systems (LLM-CDSS) in gynecologic oncology.

Approach:
  • Survey Design: A questionnaire based on the technology acceptance model (TAM) and unified theory of acceptance and use of technology (UTAUT) was sent to clinicians at a gynecology and obstetrics clinic. The survey included 29 physicians and utilized Ordinary Least Squares (O…
Key Findings:
  • OLS regression did not identify significant factors influencing willingness to use LLM-CDSS.
  • Survey responses indicated a generally positive but cautious attitude toward LLM-based therapy recommendation systems.
  • Acceptance was influenced by factors such as transparency, integration of evidence, clinical validation, and preservation of physician oversight.
Interpretation:

Participants acknowledged a potential positive impact of LLM-CDSS on clinical practice but emphasized that these tools should support rather than replace physicians.

Limitations:
  • The survey sample size was small (29 physicians).
  • The survey results indicated an acquiescence bias.
  • Further validation in a larger multicentered cohort is needed.
Conclusion:

The study provides insights into physician opinions on LLM-based therapy recommendation tools.

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