To investigate changes in test positivity for common cold coronaviruses (ccCoVs) following widespread SARS-CoV-2 infections and COVID-19 vaccinations from March 2020 to September 2024.
Key Findings:
Test positivity for ccCoVs was significantly lower after widespread SARS-CoV-2 infection and COVID-19 vaccination, indicating a potential shift in viral dynamics.
There was approximately 60% lower odds of ccCoV detection in the seasons following extensive SARS-CoV-2 immunity.
No significant change in RSV or IV positivity was observed.
Interpretation:
The decrease in ccCoV positivity may be attributed to cross-reactive immune responses among coronaviruses and changes in health behaviors post-COVID-19, such as increased hygiene practices and reduced social interactions.
Limitations:
The study is limited to a single center, which may affect generalizability.
Infection history may be difficult to ascertain due to increased home testing and lack of diagnostic testing, potentially skewing results.
Conclusion:
The findings suggest a significant reduction in ccCoV positivity following the SARS-CoV-2 pandemic, indicating potential cross-immunity effects.
