Objective:

To summarize recent advances in the use of natural products for modulating the immune microenvironment in pediatric psoriasis.

Approach:

• Review of Natural Products: The review focuses on plant extracts, active components, and compound formulations that reshape the immune microenvironment in psoriatic lesions.
• Comparison of Evidence: It distinguishes between evidence from pediatric clinical studies, adult studies, and preclinical models.
• Future Directions: The article outlines challenges and future directions for translational research in pediatric psoriasis.

Key Findings:

• Natural products exhibit multi-target and multi-pathway actions.
• They can modulate T cell subsets, cytokine networks, and skin barrier integrity.
• Natural products have relatively favorable safety profiles.

Interpretation:

Natural products have shown potential in modulating the immune microenvironment in pediatric psoriasis, but further pediatric-specific validation is needed.

Limitations:

• Natural does not automatically equate to safe, especially in pediatric populations.
• Current evidence primarily derives from adult studies and preclinical models, necessitating caution in extrapolation.

Conclusion:

Further research is needed to evaluate the role of natural products in immunomodulatory treatments for children with psoriasis.