To assess the experiences and views of representatives from existing platform trials regarding the specific barriers and facilitators involved in conducting platform trials.
Key Findings:
Platform trials have increased in initiation, particularly during the COVID-19 pandemic, but face operational complexities that may hinder their effectiveness.
Challenges include resource capacity prediction, funding acquisition, staffing, and pharmaceutical engagement, which need to be addressed to improve trial outcomes.
Limited research exists on global experiences of platform trial teams, indicating a gap in understanding that could inform future methodologies.
Interpretation:
The findings highlight the need for improved understanding and infrastructure to support platform trials, which could enhance their efficiency and effectiveness in clinical research. Recommendations for addressing identified challenges should be considered.
Limitations:
The survey may not capture all experiences due to its cross-sectional nature and potential self-selection bias.
Responses were limited to those from identified platform trials and their networks, which may not represent the broader landscape.
Conclusion:
Identifying challenges and enablers in platform trials can inform standard practice guidelines and improve trial methodologies.
by Stuart McLennan, Alexandra Griessbach, Sharon Love, Christof Manuel Schönenberger, Alain Amstutz, Lucille Sebastian, Dominique Costagliola, Inge Christoffer Olsen, Corina Silvia Rueegg, Matthew R. Sydes, Matthias Briel, Benjamin Speich
