Effects of low anterior resection syndrome after colorectal cancer resections on health-related quality of life: a systematic review and meta-analysis - Summary - MDSpire
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Effects of low anterior resection syndrome after colorectal cancer resections on health-related quality of life: a systematic review and meta-analysis
To systematically assess the effects of bowel dysfunction after colorectal cancer surgeries, as measured by the LARS score, on health-related quality of life (HRQOL), specifically using the EORTC QLQ-C30 as the primary assessment tool.
Key Findings:
LARS affects various dimensions of HRQOL, particularly social and emotional domains.
Incidence of LARS one year post-surgery is approximately 44%.
Major risk factors for LARS include female gender, total mesorectal excision, and postoperative complications.
Interpretation:
Understanding the impact of LARS on HRQOL is essential for preoperative counseling and for developing targeted interventions to improve patient care.
Limitations:
Conflicting data on the impact of LARS on HRQOL.
Exclusion of studies using non-LARS questionnaires may limit comprehensive understanding.
Potential biases in study selection or data interpretation.
Conclusion:
The study highlights the significant impact of LARS on HRQOL, emphasizing the need for tailored clinical interventions.
