Impact of Maternal Smoking Identified Through Prenatal Health Assessments on Offspring's Neurodevelopmental Disorders: Findings from a Korean Mother-Child Cohort Study - Summary - MDSpire
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Impact of Maternal Smoking Identified Through Prenatal Health Assessments on Offspring's Neurodevelopmental Disorders: Findings from a Korean Mother-Child Cohort Study

  • By

  • Chan Soon Park

  • Moonyoung Jang

  • Bongseong Kim

  • Soongu Kwak

  • Tae-Min Rhee

  • Heesun Lee

  • Hyung-Kwan Kim

  • Yong-Jin Kim

  • Jae-Won Kim

  • Kyungdo Han

  • Jun-Bean Park

  • March 11, 2026

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Objective:

To clarify the association between maternal smoking and the risk of neurodevelopmental disorders in offspring, specifically intellectual disability, ASD, and ADHD.

Approach:
    Key Findings:
    • Maternal smoking is associated with an increased risk of neurodevelopmental disorders in offspring, particularly ADHD.
    • The association with intellectual disability and ASD is less robust.
    • Cumulative smoking exposure shows a dose-response relationship with neurodevelopmental outcomes.
    Interpretation:

    The findings suggest that maternal smoking is a significant modifiable risk factor for neurodevelopmental disorders, emphasizing the need for targeted smoking cessation strategies among pregnant women.

    Limitations:
    • The study relies on self-reported smoking status, which may introduce bias and affect the reliability of findings.
    • Causal relationships cannot be definitively established due to the observational nature of the study.
    • The inability to ascertain smoking status specifically during pregnancy limits the precision of exposure assessment.
    Conclusion:

    Addressing maternal smoking during pregnancy could be crucial in preventing neurodevelopmental disorders in children and should be a public health priority.

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