Addition of CAD polygenic risk score to coronary artery calcium score enhances prediction of MACE - Summary - MDSpire

Addition of CAD polygenic risk score to coronary artery calcium score enhances prediction of MACE

  • By

  • Andrii Maryniak

  • Filip Oleszak

  • Kevin Coy

  • Eric Larson

  • Catherine Hajek

  • Shubhi Bartaria

  • Shaopeng Gu

  • Max Weaver

  • Jerome I. Rotter

  • Xiuqing Guo

  • Jingyi Tan

  • Henry J. Lin

  • Adam Stys

  • Natalia Baran

  • Tomasz Stys

  • June 4, 2026

  • 0 min

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Objective:

To compare the diagnostic utility of coronary artery calcium scores (CACS) and coronary artery disease polygenic risk scores (CAD PRS), both individually and in combination, for predicting major adverse cardiovascular events (MACE).

Key Findings:
  • Both CAD PRS and CACS were significantly associated with future MACE.
  • The area under the curve (AUC) for CACS and PRS models was comparable after covariate adjustment.
  • Combining CAD PRS with CACS significantly enhanced predictive accuracy for MACE, warranting further research in diverse populations.
Interpretation:

Integrating CACS and CAD PRS improves the predictive power for MACE compared to using either modality alone, which has important implications for clinical risk assessment.

Limitations:
  • Study population predominantly Caucasian, which may limit generalizability.
  • Further research needed to validate findings in diverse populations.
  • The retrospective nature of the study may affect the robustness of the findings.
Conclusion:

The study highlights the synergistic effect of combining CACS and CAD PRS in predicting MACE, warranting further research.

Original Source(s)

Addition of CAD polygenic risk score to coronary artery calcium score enhances prediction of MACE

  • by Andrii Maryniak, Filip Oleszak, Kevin Coy, Eric Larson, Catherine Hajek, Shubhi Bartaria, Shaopeng Gu, Max Weaver, Jerome I. Rotter, Xiuqing Guo, Jingyi Tan, Henry J. Lin, Adam Stys, Natalia Baran, Tomasz Stys

  • June 4, 2026

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