To investigate the frequency and impact of mental health and substance use disorders on tuberculosis preventive therapy (TPT) adherence and completion among people with HIV (PWHIV) initiating TPT, highlighting the significance of these factors in improving health outcomes.
Key Findings:
50% of participants completed TPT.
36% screened positive for depression symptoms.
28% screened positive for anxiety symptoms.
34% reported unhealthy alcohol use.
27% reported tobacco use.
Depression symptoms were significantly associated with lower TPT adherence (9% fewer doses) and completion (odds ratio 0.48).
Interpretation:
Depression symptoms negatively impact TPT adherence and completion among PWHIV, underscoring the need for integrated mental health support in TPT programs to improve public health outcomes.
Limitations:
Study conducted in two facilities, limiting generalizability.
Self-reported measures may introduce bias.
Potential confounding factors not addressed in the study.
Conclusion:
Mental health issues, particularly depression, are prevalent among PWHIV initiating TPT and significantly hinder adherence and completion, necessitating enhanced support services, including targeted mental health interventions.
Nationwide cohort analysis finds higher tinnitus incidence during long-term follow-up among patients with postzoster neuralgia, particularly older patients and certain comorbidities.
