To systematically summarize the biological features of immune cell senescence and its role in chronic bone diseases, with a focus on the mechanisms driving these conditions.
Key Findings:
Immune cell senescence links ageing, chronic inflammation, and bone metabolism.
Senescence affects immune cell function, leading to disrupted osteoimmune microenvironment.
The impact of immune cell senescence varies across different chronic bone diseases, with specific mechanisms at play.
Intervention strategies remain largely in preclinical or early translational stages, indicating a need for further research.
Interpretation:
The review highlights the need for a comprehensive understanding of immune cell senescence in the context of chronic bone disorders to inform future therapeutic strategies.
Limitations:
Current intervention strategies are primarily at preclinical or early translational stages, limiting immediate clinical application.
Existing literature often focuses on individual diseases rather than a systematic integration of immunosenescence across conditions, highlighting a gap in comprehensive understanding.
Conclusion:
The review provides a theoretical framework for future mechanistic studies and precision treatment of chronic bone diseases, emphasizing the need for integrated approaches.
