Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI - Summary - MDSpire

Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI

  • By

  • Francesco Sanvito

  • Catalina Raymond

  • Nicholas S. Cho

  • Jingwen Yao

  • Akifumi Hagiwara

  • Joey Orpilla

  • Linda M. Liau

  • Richard G. Everson

  • Phioanh L. Nghiemphu

  • Albert Lai

  • Robert Prins

  • Noriko Salamon

  • Timothy F. Cloughesy

  • Benjamin M. Ellingson

  • October 26, 2023

  • 0 min

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Objective:

To simultaneously obtain perfusion, permeability, and leakage effect maps in human gliomas using dynamic SAGE-EPI MRI, enhancing diagnostic capabilities.

Key Findings:
  • TRATE correlates with PSR, indicating a relationship between T2*-leakage effects and overall signal recovery, which may inform treatment strategies.
  • 94R1,ss correlates with Ktrans, linking T1-leakage effects to BBB permeability, suggesting potential for assessing tumor aggressiveness.
  • Increased TRATE is associated with aggressive tumor features, particularly in IDH wild-type glioblastomas, highlighting its prognostic value.
Interpretation:

The study supports the use of dual-echo DSC for comprehensive glioma characterization, providing insights into tumor biology and potential treatment responses.

Limitations:
  • Preliminary exploration of TRATE in human tumors with limited sample size, which may affect the robustness of findings.
  • Dependence on specific imaging parameters may affect generalizability, necessitating further validation.
Conclusion:

Dynamic SAGE-EPI MRI offers a promising approach for simultaneous assessment of perfusion, permeability, and leakage effects in gliomas, enhancing diagnostic capabilities and potentially guiding treatment decisions.

Original Source(s)

Simultaneous quantification of perfusion, permeability, and leakage effects in brain gliomas using dynamic spin-and-gradient-echo echoplanar imaging MRI

  • by Francesco Sanvito, Catalina Raymond, Nicholas S. Cho, Jingwen Yao, Akifumi Hagiwara, Joey Orpilla, Linda M. Liau, Richard G. Everson, Phioanh L. Nghiemphu, Albert Lai, Robert Prins, Noriko Salamon, Timothy F. Cloughesy, Benjamin M. Ellingson

  • October 26, 2023

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