Objective:

To systematically map the interactive networks between immune cells and stromal cells during cardiac repair and fibrosis following myocardial infarction (MI).

Approach:

Key Findings:

• Heart failure post-MI is linked to complex interactions between immune and stromal cells.
• Neutrophils exhibit dual roles in cardiac repair, influencing both inflammation and tissue damage.
• The transition from essential repair responses to pathological fibrosis is governed by an imbalance in the immune-stromal network.

Interpretation:

Limitations:

• The review does not provide specific clinical trial data or outcomes related to the proposed therapeutic strategies.
• Further research is needed to fully elucidate the mechanisms of interaction and their implications for therapy.

Conclusion:

Attribution Notice

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