Objective:

To assess within-patient changes in the contralesional corticospinal tract (CST) between primary and recurrent frontal high-grade glioma, including tract-averaged measures and spatial distribution.

Approach:

• Design and cohort: Retrospective, single-center study of 29 adults with frontal high-grade glioma, documented first recurrence, preoperative DTI at both assessments, and MRC strength of 5/5 at both time points.
• Tract reconstruction: Deterministic DTI tractography reconstructed the contralesional CST using the same anatomically guided protocol at both assessments. Tract-averaged fractional anisotropy, length, and volume were recorded.
• Spatial analysis: CST masks were normalized to MNI152 space, harmonized for laterality, and compared within patients using slice-wise and voxel-wise spatial analyses.

Key Findings:

• The supplied article context describes the study design and methods but does not provide results or numerical findings.

Interpretation:

The study was designed to test whether the contralesional CST changes between primary and recurrent disease; the provided context does not report the results needed to interpret that question.

Limitations:

• The study was retrospective and single-center.
• The cohort was restricted to adults with frontal high-grade glioma, preserved MRC strength, and successful CST reconstruction at both assessments.
• The reconstructed pathway represented the tractography-defined motor component of the CST, not the complete anatomical CST.
• The supplied excerpt does not report study results.

Sources:

• Article context supplied by the user