Reply to the Letter to the Editor: Radiation exposure and screening yield by digital breast tomosynthesis compared to mammography—results of the TOSYMA trial breast density related - Summary - MDSpire
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Reply to the Letter to the Editor: Radiation exposure and screening yield by digital breast tomosynthesis compared to mammography—results of the TOSYMA trial breast density related
To address concerns regarding radiation exposure and screening yield in the context of the TOSYMA trial, particularly in relation to the precautionary principle and its implications.
Key Findings:
Higher breast doses with DBT + SM compared to DM may be offset by improved cancer detection.
Economic evaluations, particularly considering AI's role, are essential for future public health implications.
The study's design supports generalizability across different mammography devices.
Interpretation:
The findings suggest that while radiation exposure is a concern, the potential benefits of improved cancer detection with DBT + SM warrant further investigation into risk-adapted screening strategies, balancing risks and benefits.
Limitations:
The study did not conduct a detailed quantitative risk analysis, which may limit understanding of long-term implications.
Evaluation of hard endpoints is beyond the current trial's scope.
Conclusion:
Future research should prioritize innovative technologies and risk-adapted screening strategies, with preliminary evaluations already influencing national screening programs in Germany.
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