Objective:

To explore the association between recurrent pregnancy-related abdominal colic and elevated biomarkers of endocrine-disrupting chemicals (EDCs) in a patient with a history of multiple pregnancy terminations due to severe abdominal pain.

Approach:

• Intervention: A multidomain preconception program was implemented to address EDC exposure, metabolic factors, immune-vascular factors, nutritional deficits, and gut dysbiosis.

Key Findings:

• The patient experienced recurrent severe abdominal colic linked to elevated biomarkers of phthalates and parabens.
• Extensive diagnostic evaluations did not reveal a conventional cause for the abdominal pain.
• Post-intervention, the patient had a successful pregnancy without recurrence of symptoms.

Interpretation:

This case suggests a link between elevated EDC biomarkers and pregnancy-specific gastrointestinal symptoms.

Limitations:

• Biomarkers were not measured during prior symptomatic pregnancies, limiting the ability to establish causality.
• The multifactorial nature of the intervention complicates the isolation of the impact of reduced EDC exposure.

Conclusion:

This case highlights the importance of exposure history and biomonitoring in patients with unexplained pregnancy-related morbidity.